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    A Japanese medicinal company founded in 1624 rebranded as Meishoku Cosmetics in the 1880s after its owner developed a popular acne lotion for his wife. As a result of its 400 years of experience in pharmaceuticals and cosmetics, Meishoku's cosmetics have become global bestsellers. They still sell their original acne lotion along with anti-aging creams, moisturizers, and masks.